{"id":906665,"date":"2026-06-13T22:51:13","date_gmt":"2026-06-13T22:51:13","guid":{"rendered":"https:\/\/cri-one.com\/blog\/2026\/06\/13\/from-2017-note-to-proof-of-function-how-diabetes-cure-discovery-reached-the-storefront\/"},"modified":"2026-06-13T22:51:13","modified_gmt":"2026-06-13T22:51:13","slug":"from-2017-note-to-proof-of-function-how-diabetes-cure-discovery-reached-the-storefront","status":"publish","type":"post","link":"https:\/\/cri-one.com\/blog\/2026\/06\/13\/from-2017-note-to-proof-of-function-how-diabetes-cure-discovery-reached-the-storefront\/","title":{"rendered":"From 2017 Note to Proof of Function: How Diabetes Cure Discovery Reached the Storefront"},"content":{"rendered":"<p class=\"meta\">Graduation arc &middot; Diabetes Cure Discovery &middot; Invent Deposition #3361 (2017) &rarr; Diabetes Mechanism Analysis \u2014 Proof of Function #1<\/p>\n<h2>The 2017 seed-line<\/h2>\n<p>In 2017, the entry that became <a href=\"https:\/\/cri-one.com\/store\/dbt-pof-001.html\">Diabetes Mechanism Analysis \u2014 Proof of Function #1<\/a> was written down as <strong>Invent Deposition #3361<\/strong>:<\/p>\n<blockquote>\n<p>&ldquo;Immune systemic insulin. insulin medicine to magistrate through the auto immune system immune systemic insulin. insulin medicine to magistrate through the auto immune system insulin main article: insulin therapy type 1 diabetes is typically treated with a combinations of regular and nph insulin, or synthetic insulin analogs. when insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications.[29] doses of insulin are then increased to effect.[29] http:\/\/en.wikipedia.org\/wiki\/diabetic.&rdquo;<span class=\"cr\">&mdash; &copy; 2017 Christopher Gabriel Brown<\/span><\/p>\n<\/blockquote>\n<h2>What changed between 2017 and the product on the shelf<\/h2>\n<p>The 2017 entry was a single-line directive: write down the mechanism, not the brand. Between then and the Proof of Function shipping on this storefront, the work hardened into a 300-row mechanism-analysis database: each row a candidate disease driver, each column a molecular pathway under closed-loop, design-target conditions. Patent-pending. The Proof of Function exposes the database structure, the scoring rubric, and the redaction layer that lets a partner work the IP without exposing the AES-encrypted source archive.<\/p>\n<h2>Where it sits in the four-step framework<\/h2>\n<ul>\n<li><strong>Proof of Function<\/strong> &mdash; this article&rsquo;s SKU. A working write-up against representative inputs; available for licensing review at <a href=\"https:\/\/cri-one.com\/store\/dbt-pof-001.html\">Diabetes Mechanism Analysis \u2014 Proof of Function #1<\/a>.<\/li>\n<li><strong>Tech Validation<\/strong> &mdash; bench data and reproducibility under an evaluation licence.<\/li>\n<li><strong>Eval Licence<\/strong> &mdash; supervised use of the IP package by a partner team.<\/li>\n<li><strong>Full Acquisition<\/strong> &mdash; the patent application, prior-art binder, and prosecution file transfer in full.<\/li>\n<\/ul>\n<p class=\"grad\"><a href=\"https:\/\/cri-one.com\/store\/dbt-pof-001.html\">&rarr; Open the Proof of Function: Diabetes Mechanism Analysis \u2014 Proof of Function #1<\/a><\/p>\n<p class=\"prov\">Provenance: published 2017 in the Invent Depositions collection (Invent Deposition #3361); part of an intellectual-property portfolio with U.S. patent applications dating to 2012; independently timestamped by the Internet Archive. Patent-pending. Design targets, not warranted performance. First to market &mdash; documented public offering, not a determination of patent priority.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graduation arc &middot; Diabetes Cure Discovery &middot; Invent Deposition #3361 (2017) &rarr; Diabetes Mechanism Analysis \u2014 Proof of Function #1 The 2017 seed-line In 2017, the entry that became Diabetes Mechanism Analysis \u2014 Proof of Function #1 was written down as Invent Deposition #3361: &ldquo;Immune systemic insulin. insulin medicine to magistrate through the auto immune [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[561],"tags":[],"class_list":["post-906665","post","type-post","status-publish","format-standard","hentry","category-diabetes"],"_links":{"self":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts\/906665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/comments?post=906665"}],"version-history":[{"count":0,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts\/906665\/revisions"}],"wp:attachment":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/media?parent=906665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/categories?post=906665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/tags?post=906665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}