{"id":103713,"date":"2026-02-14T00:38:49","date_gmt":"2026-02-14T00:38:49","guid":{"rendered":"https:\/\/example.com\/?p=14"},"modified":"2026-06-09T01:02:14","modified_gmt":"2026-06-09T01:02:14","slug":"14-disease-cure-research-300-diseases","status":"publish","type":"post","link":"https:\/\/cri-one.com\/blog\/2026\/02\/14\/14-disease-cure-research-300-diseases\/","title":{"rendered":"Disease Cure Research: 300 Non-Opioid Diseases, Organized by Category"},"content":{"rendered":"<p>[lcus_masonry_article]<\/p>\n<h2>A Framework, Not Just One Drug<\/h2>\n<p>Embodiment thirteen in U.S. patent application 19\/540,453 is a disease cure research framework. It encompasses research and development for cures and treatments for a plurality of diseases (e.g., 300) that typically do not use opioids. Diseases are organized into categories: infectious, cardiovascular, respiratory, gastrointestinal, endocrine, neurological, musculoskeletal, dermatological, hematologic, psychiatric, renal, hepatic, autoimmune, genetic, oncological, and metabolic. The framework supports documentation and NDA\/payment terms for each research stream.<\/p>\n<p>This is the umbrella under which the diabetes, Alzheimer&#8217;s, and Parkinson&#8217;s cure discovery methods sit. The framework does not list every disease by name in the patent but defines the categories and the principle: non-opioid, category-based, with support for documentation and commercial terms (NDA, payment) per research stream. That makes it possible to add new disease pipelines within the same intellectual and legal structure.<\/p>\n<h3>Why \u201cNon-Opioid\u201d<\/h3>\n<p>Specifying that the framework focuses on diseases that do not typically use opioids draws a clear line: the portfolio is oriented toward curative and non-addictive therapeutic pathways. It also avoids overlap with opioid-based pain or palliative research. For investors and partners, the framework signals a structured approach to many indications with a consistent philosophy.<\/p>\n<p>Figure 13 in the specification is a flowchart: header, categories, output. The application (19\/540,453) was filed February 13, 2026; the USPTO payment receipt confirms receipt and payment (Confirmation # 1134).<\/p>\n<p><em>Source: US Patent Application 19\/540,453, Section 8.13 and Figure 13.<\/em><\/p>\n<p>[\/lcus_masonry_article]<\/p>\n<p><!-- crione-related-start --><\/p>\n<div class=\"crione-rel\">\n<style>.crione-rel{margin:2em 0;padding:1.25em 0;border-top:2px solid #ddd;border-bottom:2px solid #ddd;}.crione-rel-title{font-weight:600;font-size:1.05em;margin-bottom:.75em;}.crione-rel-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(180px,1fr));gap:1em;}.crione-rel-card{display:block;text-decoration:none;color:inherit;border:1px solid #e5e5e5;border-radius:6px;padding:.75em;transition:box-shadow .15s;}.crione-rel-card:hover{box-shadow:0 4px 12px rgba(0,0,0,.08);}.crione-rel-card img{display:none;}.crione-rel-name{font-weight:500;line-height:1.3;margin-bottom:.25em;}.crione-rel-price{font-weight:600;color:#0a7;}<\/style>\n<div class=\"crione-rel-title\">Related from cri-one.com\/store<\/div>\n<div class=\"crione-rel-grid\"><a class=\"crione-rel-card\" href=\"https:\/\/cri-one.com\/store\/metallodrugdb-complete-database-acquisition-300-compounds.html\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/cri-one.com\/store\/pub\/media\/catalog\/product\/m\/e\/metallodrugdb-full-sale.png\" alt=\"MetalloDrugDB - Complete Database Acquisition (300 Compounds)\" loading=\"lazy\"><\/p>\n<div class=\"crione-rel-name\">MetalloDrugDB &#8211; Complete Database Acquisition (300 Compounds)<\/div>\n<div class=\"crione-rel-price\">$40000000.00<\/div>\n<p><\/a><a class=\"crione-rel-card\" href=\"https:\/\/cri-one.com\/store\/three-discoveries-on-the-fda-road.html\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/cri-one.com\/store\/pub\/media\/catalog\/product\/t\/h\/thumb-three-discoveries.png\" alt=\"Open Research: Where My Three Free Discoveries Sit on the FDA Road\" loading=\"lazy\"><\/p>\n<div class=\"crione-rel-name\">Open Research: Where My Three Free Discoveries Sit on the FDA Road<\/div>\n<p><\/a><a class=\"crione-rel-card\" href=\"https:\/\/cri-one.com\/store\/autophi-on-demand-three-v20-epiphany-evaluation-license.html\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/cri-one.com\/store\/pub\/media\/catalog\/product\/e\/v\/eval-30-autophi-od3.png\" alt=\"AutoPhi On Demand Three (V20 Epiphany) \u2014 Evaluation License\" loading=\"lazy\"><\/p>\n<div class=\"crione-rel-name\">AutoPhi On Demand Three (V20 Epiphany) \u2014 Evaluation License<\/div>\n<div class=\"crione-rel-price\">$796373.23<\/div>\n<p><\/a><\/div>\n<\/div>\n<p><!-- crione-related-end --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Framework, Not Just One Drug<br \/>\nEmbodiment thirteen in U.S. patent application 19\/540,453 is a disease cure research framework. It encompasses research and development for cures and treatme&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[444],"tags":[455,397,454,456,457],"class_list":["post-103713","post","type-post","status-publish","format-standard","hentry","category-therapeutic-discovery","tag-300-diseases","tag-application-19-540453","tag-disease-cure","tag-non-opioid","tag-research-framework"],"_links":{"self":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts\/103713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/comments?post=103713"}],"version-history":[{"count":4,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts\/103713\/revisions"}],"predecessor-version":[{"id":903407,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/posts\/103713\/revisions\/903407"}],"wp:attachment":[{"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/media?parent=103713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/categories?post=103713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cri-one.com\/blog\/wp-json\/wp\/v2\/tags?post=103713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}